EJN:孕期补充益生菌,改变基因甲基化

European Journal of Nutrition

2018-01-03Article

4.370

影响因子

原标题:孕期补充益生菌对母亲及其后代的肥胖相关基因DNA甲基化的影响

① 孕期补充益生菌或可减少产后肥胖和子女体重过度增长风险;② 15位孕妇随机分成益生菌组(n=7)和对照组(n=8),分析与肥胖和体重增加相关基因的DNA甲基化状态;③ 相比对照组,益生菌组妇女的DNA甲基化水平在37个基因启动子中显著降低,在1个启动子中升高;④ 益生菌组的子女中68个基因启动子DNA甲基化水平显著降低;⑤ 孕期补充益生菌或可影响产妇及其后代的肥胖和体重增加相关基因的DNA甲基化状态,进而影响健康,但该结论仍需进一步验证。

膳食 益生菌 DNA甲基化 肥胖 孕期

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Title:
The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children

DOI:
10.1007/s00394-017-1601-1

Abstract & Authors展开

Abstract:
Dietary supplementation with probiotics during pregnancy has been suggested to decrease the risk for obesity in women after delivery and to minimize excessive weight gain in their children. Epigenetic DNA methylation has been proposed to impact on gene activity, thereby providing a plausible molecular mechanism for a broad range of biological processes and diseases. This pilot study aimed to evaluate whether probiotic supplementation during pregnancy could modify the DNA methylation status of the promoters of obesity and weight gain-related genes in mothers and their children. A sample of 15 pregnant women was taken from a prospective, randomized mother and infant nutrition and probiotic study. Seven women received the probiotic supplementation and eight served as controls. The women's and their children's DNA methylation status of obesity (623 genes) and weight gain-related (433) gene promoters were analyzed from blood samples at the mean of 9.8 months (range 6.1-12.7 months) postpartum. Probiotic supplementation led to significantly decreased levels of DNA methylation in 37 gene promoters and increased levels of DNA methylation in one gene promoter in women. In their children, 68 gene promoters were significantly affected consistently with a lower level of DNA methylation in the probiotic group. On the basis of our pilot study, we suggest that probiotic supplementation during pregnancy may affect the DNA methylation status of certain promoters of obesity and weight gain-related genes both in mothers and their children, thereby providing a potential mechanism for long-lasting health effects.

All Authors:
Sanna Vähämiko,Asta Laiho,Riikka Lund,Erika Isolauri,Seppo Salminen,Kirsi Laitinen

First Authors:
Sanna Vähämiko

Correspondence:
Sanna Vähämiko

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