新型测序方法:晚期肿瘤ctDNA检出率,89%

onclive

2017-06-03

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影响因子

原标题:新型测序方法检测89%的晚期癌症患者的循环肿瘤DNA

① 一种用于循环肿瘤DNA的新的高强度基因组测序方法在89%的患者中发现了肿瘤DNA和血液中至少1个遗传改变,证明了用于检测分子异常的两种方法之间的高度一致性;② 在血液样品中也发现了73%的在肿瘤样品中发现的遗传改变;③ 在不知道肿瘤组织分析结果的情况下,研究人员在血液样本中检测到在肿瘤样本中发现的76%的可操作突变;④ 使用ctDNA进行早期癌症检测的概念是令人兴奋的,并且具有很大的潜力用作诊断工具。

循环肿瘤DNA(ctDNA) 基因组测序 癌症

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Title:
Novel Sequencing Approach Detects Circulating Tumor DNA in 89% of Patients with Advanced Cancer

Abstract & Authors展开

Abstract:
A new, high-intensity genomic sequencing approach for circulating tumor DNA uncovered at least 1 genetic change in both the tumor DNA and the blood of 89% of patients, demonstrating a high rate of concordance between 2 approaches for detecting molecular aberrations, according to a study presented at the 2017 ASCO Annual Meeting. Overall, 73% of genetic changes found in tumor samples were also found in blood samples. Also, without any prior knowledge of the analysis of tumor tissue, researchers detected 76% of the actionable mutations in blood samples that were also found in the tumor samples, said lead study author Pedram Razavi, MD, PhD, a medical oncologist at Memorial Sloan Kettering Cancer Center.

All Authors:
Jason Harris

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