EJCN:合生制剂改善青少年/儿童囊性纤维化患者的炎症指标

European Journal of Clinical Nutrition

2017-12-26Article

3.057

影响因子

原标题:合生补充剂对儿童和青少年囊性纤维化的影响:一项随机对照临床试验

① 评估合生制剂对儿童/青少年囊性纤维化(CF)患者炎症反应的影响;② 招募17名对照组(CG)、19名安慰剂-CF组(PCFG)和22名合生制剂-CF组(SCFG)进行随机、安慰剂对照双盲临床试验;③ 肺功能标志物(FEV1)和营养状态标志物的基线和最终评估之间无显著差异;④ 在PCFG和SCFG组之间,发现IL-12和髓过氧化酶之间显著的相互作用;⑤ 在SCFG组补充合生制剂后,一氧化氮代谢物(NOx)显著减少;⑥ 在细菌学阳性SCFG中,补充后发现IL-6和IL-8减少。

囊性纤维化 合生元

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Title:
Effect of synbiotic supplementation in children and adolescents with cystic fibrosis: a randomized controlled clinical trial

DOI:
10.1038/s41430-017-0043-4

Abstract & Authors展开

Abstract:
Cystic fibrosis (CF) is characterized by excessive activation of immune processes. The aim of this study was to evaluate the effect of synbiotic supplementation on the inflammatory response in children/adolescents with CF. A randomized, placebo-controlled, double-blind, clinical-trial was conducted with control group (CG, n = 17), placebo-CF-group (PCFG, n = 19), synbiotic CF-group (SCFG, n = 22), PCFG negative (n = 8) and positive (n = 11) bacteriology, and SCFG negative (n = 12) and positive (n = 10) bacteriology. Markers of lung function (FEV1), nutritional status [body mass index-for age (BMI/A), height-for-age (H/A), weight-for-age (W/A), upper-arm fat area (UFA), upper-arm muscle area (UMA), body fat (%BF)], and inflammation [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-α), IL-10, IL-6, IL-1β, IL-8, myeloperoxidase (MPO), nitric oxide metabolites (NOx)] were evaluated before and after 90-day of supplementation with a synbiotic. No significance difference was found between the baseline and end evaluations of FEV1 and nutricional status markers. A significant interaction (time vs. group) was found for IL-12 (p = 0.010) and myeloperoxidase (p = 0.036) between PCFG and SCFG, however, the difference was not maintained after assessing the groups individually. NOx diminished significantly after supplementation in the SCFG (p = 0.030). In the SCFG with positive bacteriology, reductions were found in IL-6 (p = 0.033) and IL-8 (p = 0.009) after supplementation. Synbiotic supplementation shown promise at diminishing the pro-inflammatory markers IL-6, IL-8 in the SCFG with positive bacteriology and NOx in the SCFG in children/adolescents with CF.

All Authors:
Maiara Brusco de Freitas,Emilia Addison Machado Moreira,Diane de Lima Oliveira,Camila Tomio,Julia Salvan da Rosa,Yara Maria Franco Moreno,Eliana Barbosa,Norberto Ludwig Neto,Vittoria Buccigrossi,Alfredo Guarino,Tânia Silvia Fröde

First Authors:
Maiara Brusco de Freitas

Correspondence:
Emilia Addison Machado Moreira

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