Nature Reviews:一文读懂胆汁酸-肠道菌群的对话(综述)

Nature Reviews Gastroenterology & Hepatology

2017-10-11Review

13.678

影响因子

原标题:胃肠道炎症及癌变中的胆汁酸-菌群互作

① 肠道菌群可将肝脏产生胆汁酸代谢生成非结合胆汁酸及次级胆汁酸,促进胆汁酸受体的活化;② 胆汁酸是G蛋白偶联胆汁酸受体1(TGR5)及核激素受体——法尼醇X受体(FXR)的配体;③ 胆汁酸可调节肠道菌群的组成,而肠道菌群可调节胆汁酸库的容量及组成;④ 破坏胆汁酸-菌群互作可促进炎症及胃肠道疾病表型,并促进胃肠道癌症的发展(包括结肠直肠癌与肝细胞癌);⑤ 胆汁酸在脂质平衡、碳水化合物代谢、胰岛素敏感性及先天性免疫中发挥重要作用。

胆汁酸

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Title:
Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

DOI:
10.1038/nrgastro.2017.119

Abstract & Authors展开

Abstract:
Emerging evidence points to a strong association between the gut microbiota and the risk, development and progression of gastrointestinal cancers such as colorectal cancer (CRC) and hepatocellular carcinoma (HCC). Bile acids, produced in the liver, are metabolized by enzymes derived from intestinal bacteria and are critically important for maintaining a healthy gut microbiota, balanced lipid and carbohydrate metabolism, insulin sensitivity and innate immunity. Given the complexity of bile acid signalling and the direct biochemical interactions between the gut microbiota and the host, a systems biology perspective is required to understand the liver–bile acid–microbiota axis and its role in gastrointestinal carcinogenesis to reverse the microbiota-mediated alterations in bile acid metabolism that occur in disease states. An examination of recent research progress in this area is urgently needed. In this Review, we discuss the mechanistic links between bile acids and gastrointestinal carcinogenesis in CRC and HCC, which involve two major bile acid-sensing receptors, farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5). We also highlight the strategies and cutting-edge technologies to target gut-microbiota-dependent alterations in bile acid metabolism in the context of cancer therapy.

All Authors:
Wei Jia, Guoxiang Xie, Weiping Jia

First Authors:
Wei Jia

Correspondence:
Wei Jia

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