JFF:灵芝多糖调节小鼠菌群并减少胰岛素抵抗

Journal of Functional Foods

2017-10-03Article

3.144

影响因子

原标题:灵芝多糖通过调节炎症细胞因子及肠道菌群组成而改善小鼠的胰岛素敏感性

① 高脂饮食诱导小鼠产生胰岛素抵抗后,摄入灵芝多糖(GLP);② GLP可降低血浆中的胰岛素浓度,并逆转高脂饮食诱导的系统性胰岛素抵抗;③ GLP可缓解低程度慢性炎症,并降低脂肪组织中的脂肪分解;④ GLP通过抑制附睾脂肪中激素敏感性脂肪酶、脂肪酸结合蛋白4、TNF-α及IL-6的mRNA表达,减少血浆甘油三酯及非酯化脂肪酸的外流;⑤ GLP可抑制外周组织中的异位脂肪积累及肝脏胰岛素调节的脂肪生成,并可调节与2型糖尿病发展相关的肠道菌群组成。

灵芝多糖 胰岛素抵抗

图片

Title:
Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice

DOI:
10.1016/j.jff.2017.09.032

Abstract & Authors展开

Abstract:
Ectopic lipid accumulation and low-grade chronic inflammation are critical pathogenesis of insulin resistance development. Ganoderma lucidum is a traditional Chinese herb for balancing energy homeostasis. In this research, we determined the effects of G. lucidum polysaccharides (GLP) on high-fat diet (HFD)-induced insulin resistant mice. We observed that GLP treatment decreased plasma insulin concentration and reversed HFD-induced systemic insulin resistance. Meanwhile, GLP ameliorated low-grade chronic inflammation, inducing lipolysis in adipose tissues. GLP decreased plasma triglyceride and non-esterified fatty acid outflux by suppressing mRNA expressions of hormone-sensitive lipase, fatty acid binding protein 4, tumor necrosis factor-α, and interleukin-6 in epididymal fat. Finally, GLP treatment suppressed ectopic lipid accumulation in peripheral tissues and hepatic insulin-regulated lipogenesis. GLP also regulated composition of gut microbiota implicated in type 2 diabetes mellitus development.

All Authors:
S Xu , Y Dou , B Ye , Q Wu , Y Wang , M Hu , F Ma , X Rong , J Guo

First Authors:
S Xu

Correspondence:
X Rong , J Guo

查看PDF原文

已完成

请稍等...

提示
提示